The Associate Principal Scientist will be a key contributor to multi-disciplinary drug discovery and development efforts providing an integrated understanding of DMPK properties, pharmacokinetics/pharmacodynamics (PK/PD), and drug interaction (DDI) risk of novel therapeutics

• The key responsibilities will be working on teams of highly collaborative, cross-functional scientists to discover and develop therapeutics across various modalities
• The Associate Principal Scientist will design and interpret in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile
• They will assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy
• They will author source reports and documents in support of regulatory filings
• They will independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making

This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely

• The ideal candidate must be able to work collaboratively in a fast-paced environment, drive scientific development and innovation, and have excellent interpersonal and communication skills

Bachelor’s with 10+, Master’s degree with 8+ or PhD with 5 + years of industry experience in a relevant field with a focus on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates)

• Experienced in integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies
• Experience in assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management
• Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries
• Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams
• No Travel Required

Valid Driving License

• Bachelor’s, Master’s, or PhD degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, Biology, Biophysics, Biostatistics, or relevant STEM fields
• Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines

ADME, Bioanalytical Techniques, Cell-Based Assays, Communication, DMPK, Drug Interactions, Drug Metabolism, Liquid Chromatography-Mass Spectrometry (LC-MS), Mentorship, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, Project Leadership, Strategic Thinking

$142,400.00 - $224,100.00 An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs

• The successful candidate will be eligible for annual bonus and long-term incentive, if applicable
• We offer a comprehensive package of benefits
• Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days
• More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits

Flexible Work Arrangements