• This role requires deep expertise in developing and characterizing in vivo animal models, integrating multi-omics approaches, and designing in vitro systems to interrogate disease mechanisms
• The candidate will collaborate across cross-functional teams, mentor junior scientists, and manage complex non-clinical studies, contributing to our Company’s mission of advancing novel therapeutic targets
• Independently initiate and lead discovery projects to uncover and validate therapeutic targets for cardio-renal diseases
• Establish and characterize renal, cardiovascular, and metabolic animal models, utilizing functional in vivo endpoints, tissue/plasma genomics/proteomics/transcriptomics/metabolomics, and in vitro cell-based and biochemical assays
• Develop and optimize in vitro systems and cell-based functional assays for mechanism-of-action studies and compound profiling and screening
• Integrate omics data (including single-cell transcriptomics from patient-derived tissues) to inform target selection strategies
• Leverage imaging strategies (e.g., confocal fluorescence microscopy or intravital multiphoton microscopy) to investigate quantitative disease endpoints
• Spearhead collaborative projects across multidisciplinary teams and co-manage partnerships with external academic and industry collaborators
• Present impactful findings at internal and external meetings and contribute to scientific publications and technical reports
• Diligently document research activities using electronic lab notebooks; take on shared lab-based responsibilities
• Experience in designing, executing, and interpreting in vitro and ex vivo experiments
• Strong record of impactful publications, oral and poster presentations at international conferences, and recognition for research excellence
• Proven ability to be a team player, lead collaborative cross-functional projects, and manage complex non-clinical studies
• Strategic and independent thinker with a drive to innovate and initiate, own and efficiently advance projects through the discovery pipeline

This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely

• Bachelor's (with 7 years), Master's (with 4 years) or Ph.D. (with 1 year) in Biology, Physiology or a related discipline and relevant experience in academic or industrial settings
• Extensive hands-on experience in developing and characterizing in vivo rodent models for renal (e.g

Proven ability to understand disease mechanisms and solve complex problems by undertaking innovative approaches and applying state-of-the art technologies

DKD, ADPKD, FSGS) and cardiovascular disease (e.g. heart failure, ASCVD), including survival surgeries (e.g., osmotic mini-pump implantation), cardiovascular phenotyping (echocardiography, hemodynamic assessments), renal phenotyping (glomerular filtration rate measurements, assess serum and urinary biomarkers), and/or metabolic cage measurements

• Advanced skills in scientific communication, data analysis (e.g. RStudio, GraphPad Prism, Ingenuity Pathway Analysis), statistical methods, and electronic lab documentation

Cardiovascular Diseases, Cardiovascular Surgery, In Vitro Studies, In Vivo Animal Models, In Vivo Experiment, In Vivo Models, In Vivo Studies, Phenotyping, Survival Surgeries

An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs

• The successful candidate will be eligible for annual bonus and long-term incentive, if applicable
• We offer a comprehensive package of benefits
• Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days

More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits